Page 235 - Binder2

• Peyer’s patches
• Mesenteric lymph nodes
• Lamina propria-associated dendritic cells

These sites are programmed to interpret dietary proteins
and gut flora—sorting threats from tolerable exposures.
By presenting an autoantigen at these locations, tolerizing
vaccines aim to:

• Inhibit the activation of autoreactive T cells
• Induce antigen-specific Tregs
• Create long-term immune memory of silence, not
aggression

Why Plant-Based Platforms Make This Possible

Tolerizing vaccines require a very specific delivery
profile—one that’s hard to achieve with conventional
biologics:

• The antigen must survive the digestive tract
• It must arrive intact in the small intestine
• It must avoid triggering systemic immune
responses
• It must be presented in a context that mimics
natural food exposure

Plant-based oral platforms achieve this by design:

• Encapsulation in plant tissue
Autoantigens are expressed within the cell walls of
plants like lettuce, rice, or duckweed. These walls
are composed of cellulose—resistant to human

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