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Bibliometric Analysis of Thromboprophylaxis in Orthopaedic Surgery                                   09

        absolute  risk  of  the  composite  of  deep-vein     Thrombosis  and  Haemostasis; JBJS,  The                               orthopedic, and urologic surgery. N Engl J Med. 1988;
                                                                                                                                     318(18):1162-1173.
        thrombosis, non-fatal pulmonary embolism, and         Journal of  Bone and Joint Surgery;  Arch Int
        death  from  any  cause  by  9.2%.   In  this         Med, The Archives of Internal Medicine)                                7) Eriksson BI, Borris LC, Friedman RJ, Haas S, Huisman
                                                7
                                                                                                                                     MV, Kakkar AK, Bandel TJ, Beckmann H, Muehlhofer E,
        randomized  controlled  trial  involving  2459                                                                               Misselwitz F, Geerts W; RECORD1 Study Group.
                                                                                                                                     Rivaroxaban versus enoxaparin for thromboprophylaxis
        patients     undergoing       hip     arthroplasty,   Conclusion                                                             after hip arthroplasty. N Engl J Med. 2008

        rivaroxaban showed a decrease in risk of major        Thromboprophylaxis is one of the most crucial                          6;358(26):2765-2775.
        venous  thromboembolism  by  1.6%  than               aspect  of  orthopaedic  surgery  and  remains  at                     8) Turpie AG, Haas S, Kreutz R, Mantovani LG, Pattanayak
                                                                                                                                     CW, Holberg G, Jamal W, Schmidt A, van Eickels M,
        enoxaparin.  More recent studies have replicated      the    forefront   of   research    and    surgery                     Lassen MR. A non-interventional comparison of
                    7
        similar  findings.   Thus,  factor  Xa  inhibitors  are   considerations. The present report presented a                      rivaroxaban with standard of care for thromboprophylaxis
                         8
                                                                                                                                     after major orthopaedic surgery in 17,701 patients with
        considered a viable alternative to low molecular      favourable trend towards high impact research                          propensity score adjustment. Thromb Haemost. 2014;
                                                                                                                                     111(1):94-102.
        weight  heparins  (LMWHs)  in  both  ACCP  and        within orthopedic thromboprophylaxis.   Studies
                                                                                                       4
        American  Academy  of  Orthopaedic  Surgeons          included  in  analysis  were  highly  cited  for  a                    9) Johanson NA, Lachiewicz PF, Lieberman JR, Lotke PA,
                                                                                                                                     Parvizi J, Pellegrini V, Stringer TA, Tornetta P 3rd, Haralson
        (AAOs) guidelines. 9, 10                              multitude  of  factors  like  clinical  significance,                   RH 3rd, Watters WC 3rd. American academy of
                                                                                                                                     orthopaedic surgeons clinical practice guideline on.
                                                              study  quality,  and  importance  in  orthopaedics                     Prevention of symptomatic pulmonary embolism in
                                                                        4
        Top Journals publishing on DVT prophylaxis in         research.      Such     studies    improve     our                     patients undergoing total hip or knee arthroplasty. J Bone
                                                                                                                                     Joint Surg Am. 2009; 91(7):1756-1757.
        orthopedic surgery:                                   understanding      about     the    ever-changing                      10) Falck-Ytter Y, Francis CW, Johanson NA, Curley C,

        The top three journals with the greatest number       landscape  of  anticoagulation  regimens  as  well                     Dahl OE, Schulman S, Ortel TL, Pauker SG, Colwell CW Jr.
        of publications in the list of 100 (Figure 2) were:   as DVT prophylaxis in orthopaedic surgery.   4                         Prevention of VTE in orthopedic surgery patients:
                                                                                                                                     Antithrombotic Therapy and Prevention of Thrombosis,
           1)  The     Journal    of  Thrombosis       and                                                                           9th ed: American College of Chest Physicians
                                                                                                                                     Evidence-Based Clinical Practice Guidelines. Chest. 2012;
           Haemostasis (impact factor: 4.662)                 References                                                             141(2 Suppl):e278S-e325S.

           2)  The  Journal  of  Bone  and  Joint  Surgery    1) Warren JA, Sundaram K, Anis HK, Kamath AF, Higuera
           (impact factor: 4.31)                              CA, Piuzzi NS. Have Venous Thromboembolism Rates
 a) The highest cited article:   general,  orthopaedic,  and  urologic  surgery   3) The Archives of Internal Medicine (JAMA)   Decreased in Total Hip and Knee Arthroplasty? J
                                                              Arthroplasty. 2020; 35(1):259-264.
 The  8th  edition  of  American  College  of  Chest   (1988) captured some of the earliest high quality   (impact factor: 20.77).  2) Flevas DA, Megaloikonomos PD, Dimopoulos L,

 Physician  (ACCP)  Guidelines-  Prevention  of   findings in orthopaedic thromboprophylaxis. 6  Mitsiokapa E, Koulouvaris P, Mavrogenis AF.
                                                              Thromboembolism prophylaxis in orthopaedics: an
 venous thromboembolism published in Chest in                 update. EFORT Open Rev. 2018; 3(4):136-148.

 2008 had a calculated citation density of 215.54   c) The third highest cited article:
                   25                                         3) Thompson DF, Walker CK. A descriptive and historical
 of  citations/year  since  publication.  The  most   Rivaroxaban   versus   enoxaparin   for   review of bibliometrics with applications to medical
 5
 probable  explanation  for  the  high  number  of   thromboprophylaxis after hip arthroplasty (2008)   20  sciences. Pharmacotherapy. 2015; 35(6):551-559
 citations  of  the  ACCP  guidelines  is  the  broad,   highlighted  both  the  role  of  novel  factor  Xa   15  4) Sedani A, Yakkanti R, Allegra P, Mattingly L, Aiyer A.
                                                              Thromboprophylaxis across orthopaedic surgery:
 multidisciplinary recommendations put forward   inhibitors and the driving force of arthroplasty in   Percentage of publications  10  Bibliometric analysis of the most cited articles. J Clin
 by the experts. 4  DVT literature. 7  5                      Orthop Trauma. 2021; 23;16:157-167.
                                                              5) Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama
                                                              CM, Lassen MR, Colwell CW. Prevention of venous
 b) The second highest cited article:   Rivaroxaban in thromboprophylaxis:   0  thromboembolism: American College of Chest Physicians
                        JTH   JBJS  Arch                      Evidence-Based Clinical Practice Guidelines (8th Edition).
 Reduction  in  fatal  pulmonary  embolism  and   The  literature  analysis demonstrated  that   Int Med  Chest. 2008; 133(6 Suppl):381S-453S.
                                    (JAMA)
 venous   thrombosis   by   perioperative   investigators  have  actively  studied  the  efficacy
                                                              6) Collins R, Scrimgeour A, Yusuf S, Peto R. Reduction in
 administration  of  subcutaneous  heparin  -   of   rivaroxaban   in   orthopaedic   surgery.    Figure  2:  Top three  journals  with highest   fatal pulmonary embolism and venous thrombosis by
 3
 overview  of  results  of  randomized  trials  in   Rivaroxaban  has  been  found  to  reduce  the   percentage  of articles (JTH, Journal of   perioperative administration of subcutaneous heparin.
                                                              Overview of results of randomized trials in general,
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