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damaged tissue and determine the intensity of pain response. To add to that, analgesic
effect is also caused by normalization of antioxidant system and accordingly, by the
decrease in the amount of toxic molecular products of lipid peroxidation on
cellular membranes, that modify the function of membrane-inbuilt enzymes, which
participate in ATP synthesis and in maintaining the vital activity of organs and tissues

4. Detoxication effect of ozone is revealed in correction and activation of metabolic
processes in the hepatic and renal tissues, thus ensuring their main function of
neutralization and evacuation of the toxic compounds from the organs.

5. Activation of oxygen-dependent processes. Ozone doses, however low they are,
cause the increase in the content of free and dissolved blood oxygen with rapid
intensification of enzymes that catalyze aerobic oxidation of carbohydrates, lipids and
proteins with formation of ATP energy substrate. Of great importance is the
mitochondrion activation of Н-АТP-ase, responsible for conjugation of respiratory
processes and oxidative phosphorylation, resulting in ATP synthesis.

6. Optimization of pro- and anti-oxidant systems is regarded as one of the
main effects of systemic ozone therapy which is realized through its influence on
cellular membranes and brining to balance the levels of lipid peroxidation products and
of antioxidant defense system.In response to ozone there occurs the compensatory
increase in the activity of antioxidant enzymes -superoxidismutase (SOD), catalase
and glutatioperoxidase. Due to restored aerobic metabolic reactions there is the
accumulation of NADH2 and NADPH2 which function as proton donors to
restore the oxidized components of non-enzymic antioxidant system (glutathione,
vitamin E, ascorbic acid, etc.). The use of exogenic antioxidants with preliminary
calculated dose is obligatory when high ozone concentrations are used.

7. Ozone haemostatic effect depends on the dose. High concentrations
administered for external use cause evident hyper coagulation effect, while
parenteral administration of low concentrations is characterized by the decrease in
thrombocytic and coagulative levels of hemostasis and increase in fibrinilytic activity.

8. Ozone immune-modulating effect is based on its interaction with lipid structures of
cellular membranes and depends on the chosen dose. Low ozone concentrations
promote the accumulation of ozonides on the membranes of phagocytic cells –
monocytes and macrophages. Due to ozonides these cells stimulate the cytokines
synthesis of different classes. Cytokines being biologically active peptides,
contribute to the further activation of non-specific defense system (elevation of

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