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body temperature, generation of acute-phase peptides in the liver) and, apart from
it, they activate cellular and humoral immunity. All together they facilitate the
treatment of secondary immune-deficiency. Ozone high concentrations produce
aggravating effect on the processes of lipid peroxidation in cellular membrane of the
same phagocytic cells with the accumulation of the toxic and hard products of lipid
peroxidation (malon dealdehyde and Shiff bases), which inhibit cytokines synthesis
and thus eliminate the activation of T-helpers lymphocytes, aimed at regulation of
immune globulin generation by B-lymphocytes. This effect is used in the
management of patients with auto-immune pathology (rheumatoid disease,
disseminated sclerosis, sclerodermia) without the administration of drug treatment.
Methods of ozone therapy
Presently there are nine methods of ozone therapy in medical practice

1. Direct intra-arterial and intravenous application.
2. Rectal insufflations and Bladder insufflation.
3. Intramuscular injections.
4. Major and minor autohemotherapy.
5. ozonated water.
6. ozonated saline
7. Intra-articular injection.
8. Ozone bagging, ozonated oil and inhalation of ozone.

https://youtu.be/3l4zQPZi71E

RECOMMENDATIONS
There is insufficient evidence to recommend the use of ozone therapy as a form of
alternative treatment in patients with haemotological disorders, autoimmune diseases,
ischaemia, eye conditions, ENT, obstetric and gynaecology, orthopaedic conditions,
cancer and skin disorders.

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