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VetBooks.ir  Chapter 19





             Ionizing Radiation in Veterinary Medicine



             Lisa Murphy







             INTRODUCTION TO IONIZING                           Alpha and Beta Particles
             RADIATION
                                                                Alpha particles are ionized helium atoms consisting of
             Atoms are made up of protons, neutrons, and electrons. An  two protons and two neutrons with an electrical charge
             element is defined by the number of protons in its nucleus.  of 12. The large size of alpha particles lowers their
             When the number of protons and neutrons are balanced, the  penetration capacity and makes it possible to stop them
             atom is referred to as a stable isotope. Too few or too many  with skin, clothing, or a sheet of paper, but they can
             neutrons make the atom an unstable radioisotope or radionu-  densely transfer their energy along a very short track.
             clide. Radionuclides release ionizing radiation as electromag-  External exposures are unable to penetrate skin.
             netic waves or atomic particles as they decay to form new  However, internal exposures to alpha particles can be
             (daughter) radioisotopes or stable elements. These emissions  extremely harmful. Damage from alpha particles is less
             are able to strike an electron with enough force to strip it  easily repaired compared to that from beta particles and
             away from its atom, creating an ion (Rebois and Ray, 2012).  gamma rays. Radon gas that occurs in homes emits
             Ionizing radiation can also generate highly reactive nonionic  alpha particles.
             free radicals. Hydroxyl-free radicals (OH  ), formed by the  Beta particles are high-energy, negatively-charged
             ionization of water, are responsible for the biochemical  electrons that are less densely-ionizing than alpha parti-
             abnormalities associated with radiation toxicity. Radiation  cles though able to penetrate more deeply due to their
             damage either kills cells or causes damage to molecules that  lighter weight. Beta particles are stopped by thin barriers
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             increases cancer risk, particularly when DNA is involved.  such as wood or metal. Radium 228 (  Ra), one of two
             Other health concerns include cardiovascular effects, catar-  isotopes of radium used in luminescent paints, and Iodine
                                                                    131
             acts, shortened lifespan, and effects on the immune and gas-  131 (  I) emit beta particles.
             trointestinal systems and reproduction.
                As radioactive emissions travel through cells and deposit
             a concentrated amount of energy, DNA breakage and other  Gamma Rays and X-rays
             biological damage occur. Cells can repair much but not all
             of this damage; this unrepaired damage can lead to an  Gamma rays and X-rays are highly-penetrating forms
             increased risk of cancer or adverse genetic effects in off-  of electromagnetic radiation with unionization density
             spring. Any dose of radiation could potentially cause cancer.  that varies inversely with their energy (Nussbaum and
             Other authors have previously covered ionizing radiation  Ko ¨hnlein, 2003) and are distinguishable by their source
             extensively (Henriksen and Maillie, 2003; McClellan, 2014),  (Rella, 2015). Gamma rays are emitted by unstable nuclei
             mainly as it pertains to human exposures and experimental  via radioactive decay with a fixed wavelength. X-rays
             animal data. Information regarding unintentional exposures  originate outside of the nuclei. For instance, an X-ray
             of animals to ionizing radiation is more limited.  machine that accelerates electrons through a large voltage
                Nonionizing radiation has lower energy and frequen-  collides them into a metal target. Both require thick layers
                                                                of heavy material, such as lead or concrete for shielding.
             cies and higher wavelengths than ionizing radiation.
             Common forms of nonionizing radiation that are not cov-  The cosmic radiation that astronauts and airline personnel
             ered in this chapter include ultraviolet, visible light, infra-  are exposed to consists mainly of gamma rays and
             red, microwave, and radio frequency radiation.     neutrons.




             Veterinary Toxicology. DOI: http://dx.doi.org/10.1016/B978-0-12-811410-0.00019-2
             Copyright © 2018 Elsevier Inc. All rights reserved.                                            327
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