Page 366 - The Toxicology of Fishes

346 The Toxicology of Fishes

Zebrafish — — — — — —

Medaka — — — — — —

Hallmarks of Hepatobiliary Development in ST II Medaka Compared to Related Aspects of Zebrafish Development

Description Liver and gallbladder at 45° angle, ventral view; contraction of ducts of Cuvier; Hepatic portal vein first observed draining the transverse gut tube mid-sagittal Liver and gallbladder achieve adult phenotype, with liver transverse in the rostral abdomen and gallbladder right lateral at liver caudal margin; typically achieved
merging of hepatic vein and sinus venosus to the liver hilus LOA, 4.8 mm by 16 dpf LOA, 4.9 mm Adult phenotype achieved; LOA, 5.4 mm Dpf, days post fertilization; Hr, hour; Som, number of somites produced; Hpf, hours post fertilization; LOA, loss of attachment.

Feature metamorphosis Phase II hepatic metamorphosis metamorphosis Adult phenotype
Phase II portal vein Phase II Phase II completed

Hpf Som — — — — — — — — — — — Data from Iwamatsu, T., Mech. Dev., 121, 605, 2004. Data from Watanabe, T. et al., Mech. Dev., 121, 791, 2004. Data from Matthews, R.P. et al., Dev. Biol., in press. Data from Wallace, K.N. et al., Genesis, 30, 141, 2001. Data from Field, H.A. et al., Dev. Biol., 253, 279, 2003. Data from Korzh, S. et al., Mech. Dev., 103, 137, 2001. Data from Ober, E.A. et al., Mech. Dev., 120, 5, 2003. Data from

TABLE 7.4 (cont.) Hr Dpf — — 12 — 13 — 15 — 16 19 — 21 a b c d e f g h i j Abbreviations: