Page 365 - The Toxicology of Fishes

Liver Toxicity 345

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gata6, b foxA3 b gata6, b foxA3 b gata6, b foxA3 b gata6, b foxA3 b foxA3 b foxA3 b — — — — — — — — — —

At ~86 hpf, a sole prehepatic vein (PHV), the primordia of which can be observed
atrium, ventricle, bulbus arteriosus are differentiated; swim bladder emerges at
to form in the outer yolk epithelium at 24 hpf, begins to drain the caudal liver
Pineal anlage disc shaped on dorsal surface of third ventricle; sinus venosus,

into the left duct of Cuvier Left lateral longitudinal liver leaflet (L5) is well distinguished at 86 hpf Bile autofluorescence in gallbladder first observed at 88 hpf; onset of bile synthesis suspected to be earlier Somite formation completed; air bladder vacuolar body at third somites; kidneys bilateral at first somites Tubular spinal chord apparent Gut tube and pericardium distinguished; pericardial cavity forms; teeth are visible; linear gut tub

third somite 3.3 mm translocation

Pineal gland Hepatic vein L5 phenotype Bile synthesis Somites complete Spinal chord Gut/pericardium Spleen Hatching Peristalsis Phase I metamorphosis Pectoral fin activity/ immotility Alimentary canal Respiration Phase II metamorphosis Phase II metamorphosis

74 86 86 88 — —
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34 35 35 — — —
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2 10 10 — — —
5 12 — — —

3 4 5 7 8 9 10