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200  Section E: Other Forms of Structural Heart Disease


              Table 15.2.  Criteria	for	diagnosis	of	infective	endocarditis

               Definite	Infective	Endocarditis

               •	 Pathologic	criteria
                 •	 Micororganisms	demonstrated	by	culture	or	histology	in	vegetation	(of	valve	or	embolization)
                 •	 Active	endocarditis	confirmed	on	histology
               •	 Clinical	criteria	(see	Table	15.1)
                 •	 Two	major	criteria
                 •	 One	major	and	three	minor	criteria
                 •	 Five	minor	criteria
               Possible	Infective	Endocarditis
      Misc. Heart Diseases  •	 Findings	consistent	with	infective	endocarditis,	but	which	fall	short	of	“definitive”	description	above


               Reject	Infective	Endocarditis	Diagnosis
               •	 Good	alternative	diagnosis
               •	 Clinical	signs	resolve	with	<4	days	of	antimicrobial	therapy
               •	 No	pathologic	evidence	of	infective	endocarditis	at	surgery	or	postmortem	(after	<4	days	of	antimicrobial	therapy)

              Modified	from	Miller	and	Sisson	1999,	p.	572.

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