Page 25 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

xxiv Contents

989
VetBooks.ir Toxicodynamics 989 72. Ochratoxins and Citrinin
Mechanisms of Action
Ramesh C. Gupta, Ajay Srivastava
Immunotoxic Effects
989
Reproductive and Teratogenic Effects 990 and Rajiv Lall
Toxicopathology of Aflatoxins 990 Introduction 1019
Clinicopathology 990 Background 1019
Macroscopic and Microscopic Pathology 991 Toxicokinetics 1020
Treatment and Preventative Antidotes 992 Mechanism of Action 1021
Aflatoxin Interactions 992 Nephrotoxicity 1021
Concluding Remarks and Future Directions 992 Neurotoxicity 1021
References 993 Immunotoxicity 1022
Carcinogenicity 1022
70. Ergot and Fescue Toxicoses Toxicity 1022
Diagnosis 1024
Ramesh C. Gupta, Tim J. Evans and Treatment 1024
Steven S. Nicholson Concluding Remarks and Future Directions 1024
Acknowledgment 1024
Introduction 995
Background 995 References 1025
Pharmacokinetics/Toxicokinetics 996
Mechanism of Action 996 73. Slaframine
Toxicity 998
Geof W. Smith
Treatment 1000
Concluding Remarks and Future Directions 1000 Introduction 1029
References 1000 Background 1029
Chemistry and Toxicokinetics 1029
Mechanism of Action 1029
71. Fumonisins
Toxicity 1030
Geof W. Smith Diagnosis and Treatment 1031
Concluding Remarks and Future Directions 1031
Introduction 1003
References 1031
Background 1003
Chemical Structure 1003 74. Tremorgenic Mycotoxins
Occurrence and Distribution 1003
Pharmcokinetics/Toxicokinetics 1004 Tim J. Evans and Ramesh C. Gupta
Mechanism of Action 1005
Introduction 1033
Sphingolipid Alterations 1005
Background 1033
Toxicity 1006 Penicillium-Associated Tremorgenic
Spontaneous and Experimental Fumonisin Mycotoxins 1033
Toxicosis in Swine 1006
Fumonisins in Swine-Pulmonary Effects 1007 Aspergillus-Associated Tremorgenic 1035
Mycotoxins
Fumonisins in Swine-Hepatic Effects 1010
Neotyphodium-Associated Tremorgenic
Fumonisins in Swine-Cardiovascular Effects 1010
Mycotoxins 1036
Fumonisins in Swine-Immunologic Effects 1010
Claviceps-Associated Tremorgenic
Fumonisin Toxicosis in Horses-Historical 1011
Mycotoxins 1036
Spontaneous and Experimental Fumonisin
Bermudagrass Staggers 1036
Toxicosis in Horses 1012
Toxicokinetics 1036
Neurologic and Hepatic Effects in Horses 1012
Mechanism of Action 1037
Fumonisin Toxicity in Cattle 1014
Toxicodynamics 1037
Fumonisin Toxicity in Poultry 1015
Central Effects 1037
Diagnosis and Treatment 1015
Peripheral Effects 1038
Concluding Remarks and Future Directions 1016
Genotoxicity 1038
References 1016
Acute Toxicity 1038
Further Reading 1018
Potential Interactions 1038