Page 257 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

224 SECTION | II Organ Toxicity

VetBooks.ir inadvertently given zinc phosphide were found dead with proteolysis, tissue destruction, emphysema, and death
At high doses, MI leads to pulmonary edema, excess
no clinical signs after the flooring of a slat-and-litter
within 6 24 h after the onset of clinical signs (Pickrell
house was breached (Tiwary et al., 2005). Gross necropsy
revealed intense congestion of the viscera; histopathologic and Oehme, 2004). Several pounds of green forage con-
examination revealed severe pulmonary edema and con- taining 4-ipomeanol may be fatal to a cow within 1 2
gestion of the chickens’ lungs, hearts, livers and kidneys days (Nicholson, 2004). At lower exposure levels, animals
(Tiwary et al., 2005). may have respiratory signs (depression, respiratory grunt,
wheeze, and froth flowing out of the nostrils) but will
Smoke recover within 24 72 h with minimal to no physiological
impairment. However, proliferation of type II alveolar
Smoke inhalation injury is common in animals when con-
cells may persist with no demonstrable physiological con-
finement does not allow them to move away from smoke-
sequences. If exercised, cattle with intermediate signs can
filled air. Cardiac dysfunction in sheep following com-
be pushed into the acute syndrome; they will worsen rap-
bined burn and smoke injury was mostly related to hypo-
idly, develop significant lung edema and may die
volemia, and was improved by aggressive fluid therapy.
(Pickrell and Oehme, 2004).
However, later myocardial contractile dysfunction seemed
to be correlated with smoke inhalation injury (Soejima
et al., 2001). In chickens, the interparabronchial septal
spaces were measurably thickened and engorged as a REFERENCES
result of hydrostatic pulmonary edema, similar to the
effect of hydrostatic pulmonary edema in mammals Ammann, V.J., Vrins, A.A., Lavoie, J.P., 1998. Effects of inhaled beclo-
(Weidner et al., 2002). Under similar conditions, air sacs methasonedipropionate on respiratory function in horses with chronic
obstructive pulmonary disease (COPD). Equine. Vet. J. 30 (2),
thickened, and microvilli had increased density (Weidner,
152 157.
2000).
Bedenice, D., Heuwieser, W., Brawer, R., et al., 2003. Clinical and prog-
nostic significance of radiographic pattern, distribution, and severity
Overheated Frying Pans of thoracic radiographic changes in neonatal foals. J. Vet. Intern.
Exposure of caged birds to gases released from overheated Med. 17 (6), 876 886.
nonstick cookware has been shown to result in a high per- Berny, P., 2007. Pesticides and the intoxication of wild animals. J. Vet.
centage of deaths (Brown et al., 1997). Most of these birds Pharmacol. Ther. 30, 93 100.
Borm, P., Klaessig, F.C., Landry, T.D., et al., 2006. Research strategies
have pulmonary edema and hemorrhages. Proximity to the
for safety evaluation of nanomaterials. Part VI. Characterization of
source is an important risk factor. Birds in adjacent rooms
nanoscale particles for toxicological evaluation. Toxicol. Sci. 90 (2),
may have only minimal pulmonary reactions compared to
23 32.
birds close to the source, even when the total exposure is
Brown, R.E., Brain, J.D., Wang, N., 1997. The avian respiratory system:
similar for both (Brown et al., 1997). The mechanisms of a unique model for studies of respiratory toxicosis and for monitor-
these differences are not known at this time. It has been ing air quality. Environ. Health Perspect. 105 (2), 188 200.
suggested that physical chemical changes occur in Carson, T.L., 2004. Gases. In Clinical Veterinary Toxicology, Plumlee
released substances over time, making them less toxic. KH (ed.), St. Louis, MO, pp. 155 161.
Alternatively, particles released from overheated surfaces Cope, R.B., Camp, C., Lohr, C.V., 2004. Fatal yew (Taxus sp.) poisoning
in the same room are smaller in diameter, and more in Willamette Valley, Oregon, horses. Vet. Hum. Toxicol. 46 (5),
numerous, closer to the source, whereas those further 279 281.
Corcoran, T.E., 2010. A better picture of clearance in the nose. J. Appl.
away tend to coalesce into larger particles. Thus, birds in
Physiol. 108, 1 2.
the same room would be exposed to more surface areas
Cox, R.A., Soejima, K., Burke, A.S., et al., 2001. Enhanced pulmonary
per unit mass than those in adjacent rooms.
expression of endothelin-1 in an ovine model of smoke inhalation
injury. J. Burn. Care Rehabil. 22 (6), 375 383.
Tryptophan and Perilla Frutescens Crowell, W.A., Whitlock, R.H., Stout, R.C., Tyler, D.E., 1979. Ethylene
Tryptophan toxicity is associated with cattle consuming glycol toxicosis in cattle. Cornell. Vet. 69 (3), 272 279.
tryptophan in lush green forages (Pickrell and Oehme, Davis, E., Rush, B.R., 2002. Equine recurrent airway obstruction: patho-
genesis, diagnosis, and patient management. Vet. Clin. North Am.
2004). The rumen converts tryptophan to 3-methyl indole
Equine. Pract. 18 (3), 453 467.
(MI), which is metabolically activated by cytochrome
Dickinson, C.E., Traub-Dargatz, J.L., Dargatz, D.A., et al., 1996.
P450 to a reactive compound in the lung. In a similar tox-
Rattlesnake venom poisoning in horses: 32 cases (1973 1993).
icosis, perilla ketone and 4-ipomeanol from Perilla frutes- J. Am. Vet. Med. Assoc. 208 (11), 1866 1871.
cens (beef steak plant) damage endothelial cells and Drobatz, K.J., Saunders, H.M., Pugh, C.R., et al., 1995. Noncardiogenic
type I pulmonary epithelium (Nicholson, 2004; Pickrell pulmonary edema in dogs and cats: 26 cases (1987 1993). J. Am.
and Oehme, 2004). Vet. Med. Assoc. 206 (11), 1732 1736.