Page 1465 - Small Animal Internal Medicine, 6th Edition

CHAPTER 92 Practical Antimicrobial Chemotherapy 1437

TABLE 92.1
VetBooks.ir Antibiotics Used for the Treatment of Bacterial Infections in Dogs and Cats and General Dosing Guidelines*

ADMINISTRATION
DRUG MECHANISM SPECIES DOSAGE ROUTE OF
Acetamides Protein synthesis inhibition
Chloramphenicol D 25-50 mg/kg, q8h PO
C 50 mg/cat q12h PO
Florfenicol D 20 mg/kg, q6h PO, IM
Aminoglycosides † Protein synthesis inhibition
Amikacin D 15-30 mg/kg, q24h IV, IM, SC
C 10-14 mg/kg, q24h IV, IM, SC
Gentamicin D 9-14 mg/kg, q24h IV, IM, SC
C 5-8 mg/kg, q24h IV, IM, SC
Neomycin B 10-20 mg/kg, q6-12h PO
Carbapenems Cell wall synthesis
inhibition
Imipenem-cilastatin B 5 mg/kg, q6-8h IV, IM
Meropenem 8.5 mg/kg, IV, SC
q12h (SC) or q8h (IV)
Cephalosporins Cell wall synthesis
inhibition
Cefadroxil (first generation) D 22-30 mg/kg, q12h PO
C 22 mg/kg, q24h PO
Cefpodoxime (third B 5-10 mg/kg, q24h PO
generation)
Cephalexin (first generation) B 10-30 mg/kg, q8-12h PO
Cefazolin (first generation) B 20-35 mg/kg, q6-12h SC, IM, IV
Cefoxitin (second generation) B 15-30 mg/kg, q6-8h SC, IM, IV
Cefotaxime (third generation) B 20-80 mg/kg, q8-12h SC, IM, IV
Cefovecin B 8 mg/kg, once, can repeat SC
in 7-14 days
Ceftiofur Naxcel B 2.2-4.4 mg/kg, q24h SC
Macrolides/lincosamides Protein synthesis inhibition
Azithromycin D 5-10 mg/kg, on day 1 PO
then q3d
Clindamycin D 10 mg/kg, q12h PO, SC
C 5-15 mg/kg, q12h PO, SC
Erythromycin B 10-20 mg/kg, q8-12h PO
Lincomycin B 15-25 mg/kg, q12h PO
Tylosin B 5-15 mg/kg, q12-24h PO
Nitroimidazole Protein synthesis inhibition
Metronidazole § B 10-25 mg/kg, q12-24h PO
B 10 mg/kg, q8h IV
Ronidazole B 30 mg/kg, q24h PO
Penicillins Cell wall synthesis
inhibition
Amoxicillin B 22 mg/kg, q12h PO
Amoxicillin and clavulanate D 11 mg/kg, q8-12h PO
C 62.5 mg, q8-12h PO
Continued