Page 47 - Withrow and MacEwen's Small Animal Clinical Oncology, 6th Edition

26 PART I The Biology and Pathogenesis of Cancer

FIV-positive cats remain positive despite these therapies. A sin- 13. Lingaas F, Comstock KE, Kirkness EF, et al.: A mutation in the
gle inactivated FIV vaccine has been licensed for use in domestic canine BHD gene is associated with hereditary multifocal renal
cystadenocarcinoma and nodular dermatofibrosis in the German
cats. However, this is an adjuvanted vaccine, and it may be asso-
VetBooks.ir ciated with an increased risk of vaccine-associated sarcoma. The 14. Karlsson EK, Sigurdsson S, Ivansson E, et al.: Genome-wide analy-
Shepherd dog, Hum Mol Genet 12:3043–3053, 2003.
primary concern with the vaccine is that it generates antibodies
that cross-react with the currently recommended antibody-based ses implicate 33 loci in heritable dog osteosarcoma, including regu-
latory variants near CDKN2A/B, Genome Biol 14:R132, 2013.
diagnostic test for FIV infection. PCR-based tests are not cur- 15. Peto R: Quantitative implications of the approximate irrelevance
rently considered reliable for diagnosis of FIV, and antibody- of mammalian body size and lifespan to lifelong cancer risk, Philos
based testing remains the gold standard. 409 It is important to Trans R Soc Lond B Biol Sci 370, 2015.
note that the AAFP does not recommend the use of an FIV vac- 16. Abegglen LM, Caulin AF, Chan A, et al.: Potential mechanisms for
cine in domestic cats. cancer resistance in elephants and comparative cellular response to
DNA damage in humans, JAMA 314:1850–1860, 2015.
Comparative Aspects 17. Sulak M, Fong L, Mika K, et al.: TP53 copy number expansion
is associated with the evolution of increased body size and an
The association between human viruses and certain cancers has enhanced DNA damage response in elephants, Elife 5, 2016.
been established on the basis of epidemiologic, clinical, and 18. Keane M, Semeiks J, Webb AE, et al.: Insights into the evolution of
longevity from the bowhead whale genome, Cell Rep 10:112–122,
molecular studies. 277 Human T-cell leukemia virus (HTLV-1) has 2015.
been linked to adult T-cell leukemia. More than 100 papilloma- 19. Park JY, An YR, An CM, et al.: Evolutionary constraints over mic-
viruses occur in humans; these are believed to be responsible for rosatellite abundance in larger mammals as a potential mechanism
cervical cancer; for 25% to 60% of SCCs of the oral cavity; and in against carcinogenic burden, Sci Rep 6:25246, 2016.
33
rare cases some SCCs that occur on the skin surface. The human 20. Selman C, Nussey DH, Monaghan P: Ageing: it’s a dog’s life, Curr
papillomavirus (HPV) is associated with cervical cancer. The Biol 23:R451–453, 2013.
Epstein-Barr virus (EBV) is related to the development of Burkitt 21. Larson G, Karlsson EK, Perri A, et al.: Rethinking dog domesti-
lymphoma and nasopharyngeal carcinoma, and the human hepa- cation by integrating genetics, archeology, and biogeography, Proc
titis B and hepatitis C viruses are associated with hepatocellular Natl Acad Sci U S A 109:8878–8883, 2012.
carcinoma. The human herpes virus (HHV) is implicated in the 22. Longhi A, Pasini A, Cicognani A, et al.: Height as a risk factor for
osteosarcoma, J Pediatr Hematol Oncol 27:314–318, 2005.
development of Kaposi sarcoma. 23. Mirabello L, Pfeiffer R, Murphy G, et al.: Height at diagnosis and
birth-weight as risk factors for osteosarcoma, Cancer Causes Control
References 22:899–908, 2011.
24. Troisi R, Masters MN, Joshipura K, et al.: Perinatal factors, growth
1. Townsend N, Wilson L, Bhatnagar P, et al.: Cardiovascular disease and development, and osteosarcoma risk, Br J Cancer 95:1603–
in Europe: epidemiological update 2016, Eur Heart J 37:3232– 1607, 2006.
3245, 2016. 25. Anfinsen KP, Grotmol T, Bruland OS, et al.: Breed-specific inci-
2. Heron M, Anderson RN: Changes in the leading cause of death: dence rates of canine primary bone tumors—a population based
recent patterns in heart disease and cancer mortality, NCHS Data survey of dogs in Norway, Can J Vet Res 75:209–215, 2011.
Brief1–8, 2016. 26. Phillips JC, Stephenson B, Hauck M, et al.: Heritability and segre-
3. Adams VJ, Evans KM, Sampson J, et al.: Methods and mortality gation analysis of osteosarcoma in the Scottish deerhound, Genom-
results of a health survey of purebred dogs in the UK, J Small Anim ics 90:354–363, 2007.
Pract 51:512–524, 2010. 27. Melin M, Rivera P, Arendt M, et al.: Genome-wide analysis
4. Bonnett BN, Egenvall A, Hedhammar A, et al.: Mortality in over identifies germ-line risk factors associated with canine mammary
350,000 insured Swedish dogs from 1995-2000: I. Breed-, gender-, tumours, PLoS Genet 12:e1006029, 2016.
age- and cause-specific rates, Acta Vet Scand 46:105–120, 2005. 28. Karyadi DM, Karlins E, Decker B, et al.: A copy number variant
5. Proschowsky HF, Rugbjerg H, Ersboll AK: Mortality of purebred at the KITLG locus likely confers risk for canine squamous cell
and mixed-breed dogs in Denmark, Prev Vet Med 58:63–74, 2003. carcinoma of the digit, PLoS Genet 9:e1003409, 2013.
6. Moore GE, Burkman KD, Carter MN, et al.: Causes of death or 29. Savage SA, Mirabello L, Wang Z, et al.: Genome-wide association
reasons for euthanasia in military working dogs: 927 cases (1993- study identifies two susceptibility loci for osteosarcoma, Nat Genet
1996), J Am Vet Med Assoc 219:209–214, 2001. 45:799–803, 2013.
7. Nowell PC, Hungerford DA: A minute chromosome in human 30. Mirabello L, Koster R, Moriarity BS, et al.: A genome-wide scan
chronic granulocytic leukemia, Science 132:1497, 1960. identifies variants in NFIB associated with metastasis in patients
8. Nowell PC, Hungerford DA: Chromosome studies in human with osteosarcoma, Cancer Discov 5:920–931, 2015.
leukemia. II. Chronic granulocytic leukemia, J Natl Cancer Inst 31. Hanahan D, Weinberg RA: Hallmarks of cancer: the next genera-
27:1013–1035, 1961. tion, Cell 144:646–674, 2011.
9. Albuquerque TAF, Drummond do Val L, Doherty A, et al.: From 32. Hanahan D, Weinberg RA: The hallmarks of cancer, Cell 100:57–
humans to hydra: patterns of cancer across the tree of life, Biol Rev 70, 2000.
Camb Philos Soc 93:1715–1734, 2018. 33. Ley TJ, Mardis ER, Ding L, et al.: DNA sequencing of a cytogenet-
10. Tomasetti C, Li L, Vogelstein B: Stem cell divisions, somatic muta- ically normal acute myeloid leukaemia genome, Nature 456:66–72,
tions, cancer etiology, and cancer prevention, Science 355:1330– 2008.
1334, 2017. 34. Hahn WC, Weinberg RA: Modelling the molecular circuitry of
11. Tomasetti C, Vogelstein B: Cancer etiology. Variation in cancer risk cancer, Nat Rev Cancer 2:331–341, 2002.
among tissues can be explained by the number of stem cell divi- 35. Ruchatz H, Coluccia AM, Stano P, et al.: Constitutive activation
sions, Science 347:78–81, 2015. of Jak2 contributes to proliferation and resistance to apoptosis in
12. Tomasetti C, Vogelstein B, Parmigiani G: Half or more of the NPM/ALK-transformed cells, Exp Hematol 31:309–315, 2003.
somatic mutations in cancers of self-renewing tissues originate 36. Modiano JF, Ritt MG, Wojcieszyn J, et al.: Growth arrest of mela-
prior to tumor initiation, Proc Natl Acad Sci U S A 110:1999–2004, noma cells is differentially regulated by contact inhibition and
2013. serum deprivation, DNA Cell Biol 18:357–367, 1999.