Page 642 - Withrow and MacEwen's Small Animal Clinical Oncology, 6th Edition

620 PART IV Specific Malignancies in the Small Animal Patient

TABLE 28.8 Prognostic Factors and Indications for Adjuvant Chemotherapy with Level of Supporting Evidence in
Cats with Malignant Mammary Tumors
VetBooks.ir Tumor Size Lymph Node Involvement Histopathologic Indication for Evidence Level a
Chemotherapy No or Yes
Parameters
<2 cm /8 cm 3 Negative Carcinoma No 1 220
Yes b 3 210,217,221
2–3 cm/8–27 cm 3 Negative Carcinoma No 3 219,222
Yes b 3 210,217,221
>3 cm/ 27 cm 3 Negative Carcinoma Yes 1, 220 2, 199 3 219,222
Any Positive Carcinoma Yes 2, 199 3, 217 5 80

a Evidence level 1: Prospective randomized trial; level 2: Prospective, nonrandomized trial; level 3: Retrospective; level 5: Extrapolation from human breast cancer studies.
b Vascular invasion and high grade were found to be independent negative prognostic factors in multivariate analysis.

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