Page 627 - Clinical Small Animal Internal Medicine

55 Pancreatitis in the Dog 595

Table 55.2 Summary of sensitivity and specificity for various laboratory testing in dogs from various studies
VetBooks.ir Study Number of dogs Method of diagnosis Analyte assessed Sensitivity (%) Specificity (%)

Haworth et al. J Vet n = 38 Clinical evaluation of SNAP‐cPL 82 59
Emerg Crit Care AP = 11 dogs presenting with Spec‐cPL >400 μg/L 70 77
2014;24(2):135–43 Non AP = 26 acute abdominal
disease
Chartier et al. Vet J n= 14 AP Clinical evaluation Peritoneal CPL 100 94.7
2014;201:385–9 n = 19 non‐AP (11 pure/ >500 μg/L
modified transudate, 1 Peritoneal amylase 71.4 84.2
septic exudate, 2 nonseptic >1050 U/L
exudate and 5 hemorrhagic
effusion) Peritoneal total 92.9 94.7
lipase >500 U/L
McCord et al. J Vet n = 84 Combination of Spec‐cPL >400 μg/L 71.7–77.8 80.5–88
Intern Med AP = 57 clinical and imaging Lipase 43.4–53.6 89.3–92.5
2012;26:888–96 Non‐AP = 27 results
Amylase 52.4–56 76.7–80.6
Mansfield et al. J Vet n = 32 Histology Spec‐cPL >400 μg/L NA 90
Diag Invest Minimal/no inflammation
2012;24:312–18 = 20
Trivedi et al. J Vet n = 70 Histology Spec‐cPL >400 μg/L 21 (mild) 100
Intern Med Mild AP = 56 71 (mod‐severe)
2011;25:1241–7 Moderate‐severe AP = 7 TLI 30 (mild) 100
Normal pancreas = 7 29 (mod‐severe)

Lipase 54 (mild) 43
71 (mod‐severe)
Amylase 7 (mild) 100
14 (mod‐severe)
Mansfield et al. J Vet n = 61 Histology CPE‐1 >17.24 ng/mL 61.4 (all) 91.7
Diag Invest AP = 41 66 (AP)
2011;23:691–7 CP = 3 78 (severe AP)
Pancreatic carcinoma = 5
Nonpancreatitis = 12
Neilson‐Carley et al. n = 64 Histology Spec‐cPL >400 μg/L NA 95%
Am J Vet Res AP = 20
2011;72:302–7 Other disease = 17
Healthy = 27
Steiner et al. Vet Ther n = 22 Gross evidence at Spec‐cPL >400 μg/L 63.6 NA
2008;9:263–73 postmortem Lipase 31.8 NA
Amylase 40.9 NA
Steiner et al. J Vet n = 11 Clinical findings and Spec‐cPL >400 μg/L 88 NA
Intern Med (Severe AP) histology
2001;15:274
Mansfield and Jones n = 42 Clinical findings and Lipase >3 × RI 63.6 54.6
Aust Vet J AP = 15 histology Amylase >3 × RI 22.7 78.1
2000;78:416–22 Non‐AP = 27
TLI >100 μ/L 37.5 89.3
Source: Adapted from Mansfield (2013).
AP, acute pancreatitis; CP, chronic pancreatitis; CPE‐1, serum canine pancreatic‐elastase‐1; cPL, canine pancreatic lipase (or canine pancreatic
lipase immunoreactivity in earlier studies); NA, not assessed; RI, reference interval; TLI, trypsin‐like immunoreactivity.