Page 149 - Veterinary Immunology, 10th Edition

of an unpaired electron):
VetBooks.ir

FIG. 5.14 The major features of the respiratory burst pathway in
neutrophils. Binding of opsonized bacteria to phagocytic receptors
such as CD32 triggers the process. It results in the assembly of the
multicomponent enzyme NADPH oxidase (NOX) in the membrane
of the phagosome. Once assembled, NOX catalyzes the generation
of singlet oxygen. In association with other enzymes such as
superoxide dismutase and myeloperoxidase, bactericidal products
−
such as hydrogen peroxide (H O ) and hypochlorite ions (OCl ) are
2 2
then generated.

Two superoxide anions interact spontaneously (dismutate) to
generate one molecule of H O under the influence of the enzyme
2 2
superoxide dismutase:

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