Page 399 - Veterinary Immunology, 10th Edition

example, CD4, found only on helper T cells, binds MHC class II
VetBooks.ir molecules on antigen-presenting cells. CD8, in contrast, is found

only on cytotoxic T cells and binds MHC class Ia molecules on
virus-infected or other abnormal cells. Both CD4 and CD8 enhance

TCR signal transduction by linking the T cell to an antigen-
presenting cell through the MHC.

FIG. 14.6 Role of CD4 and CD8 in promoting T cell responses.
These molecules link the T cell to the antigen-presenting cell,
binding the two cells together and ensuring that an effective signal
is transmitted between them. This interaction is seen in Fig. 10.6, A.

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