Page 403 - Veterinary Immunology, 10th Edition
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FIG. 14.8 The induction of Th17 cells by exposure to a cytokine
mixture containing TGF-β and IL-6. Differentiation is promoted by
IL-21 and maintained by IL-23. Th17 cells promote neutrophil
accumulation and acute inflammation.
Adhesion Molecules
In addition to the dialog mediated by co-stimulatory molecules, T
cells and antigen-presenting cells stimulate each other most
effectively if they are linked by adhesion molecules such as the
integrins. For example, CD2 and CD11a/CD18 on T cells bind to
their ligands CD58 and CD54 on antigen-presenting cells and bind
the cells together. Once tightly bound, an immunological synapse
forms where the cells come into contact.
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