Page 424 - Veterinary Immunology, 10th Edition

T cells may well be major contributors to innate immunity,
VetBooks.ir especially since many of them have non-polymorphic TCRs. They

recognize microbial glycolipids presented by CD1-positive antigen-
presenting cells and release cytokines and lyse target cells just like

conventional α/β NKT cells (Chapter 19). The role of γ/δ T cells on
mucosal surfaces is discussed further in Chapter 22. Some bovine γ/
δ Τ cells serve a regulatory function. They spontaneously secrete IL-
+
10 and can inhibit antigen-specific and nonspecific CD4 and CD8 +
T cell proliferation in vitro.
Pigs also have multiple phenotypically distinct subpopulations of
γ/δ T cells. Some may produce IFN-γ alone, TNF-α alone, or both
IFN-γ and TNF-α. Other subpopulations can produce IL-17. Some

have differing levels of TCR γ/δ expression.

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