Page 447 - Veterinary Immunology, 10th Edition
P. 447
The B cell–stimulating ligands include flagellins,
VetBooks.ir lipopolysaccharides, and CpG DNA. Signaling by TLR4 enhances B
cell antigen presentation, promotes germinal center formation, and
is required for optimal antibody production against T-dependent
antigens. TLR signaling to memory B cells increases antibody
production, but it does not appear to be required for IgA and IgE
production. Thus TLR signaling can substitute in part for T cell help
and explains why antibody production still occurs in AIDS patients
despite their lack of T cells.
447
