Page 522 - Veterinary Immunology, 10th Edition
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apoptosis without participating in an immune response.
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FIG. 17.8 During its development, each B cell has four attempts to
make a productive gene rearrangement coding for a functional
immunoglobulin. If it fails in all four attempts, the cell undergoes
apoptosis.
The sequence of events described above has been worked out in
mice and humans; the details differ in domestic mammals. One
obvious difference lies in the use of κ and λ light chains. In mice,
rabbits, pigs, and humans, κ chains are preferentially used. In the
other domestic species, λ light chains predominate. The reasons for
these differences are unknown.
It should also be pointed out that immunoglobulin gene
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