Page 520 - Veterinary Immunology, 10th Edition

genes also occurs in a specific order. Thus IGHD is first joined to
VetBooks.ir IGHJ, and then IGHV is attached to make a complete V-region gene.

After transcription, any unwanted J genes are deleted, the IGHC
gene mRNA is attached, and the completely assembled V-D-J-C

mRNA is translated to form a heavy chain.

FIG. 17.7 Construction of a complete immunoglobulin heavy chain
gene. Two DNA rearrangement events are required to link V, D, and
J genes together. The first event joins selected D and J genes; the
second event adds a selected V gene. Finally, unwanted J genes
are excised and VDJ joined to C in the mRNA.

Base Deletion

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