Page 539 - Veterinary Immunology, 10th Edition

and many are pseudogenes. When sources differ, the author has chosen the highest
VetBooks.ir number of genes reported since as genetic analysis proceeds, more and more genes are

being identified, and these numbers may be expected to rise.

FIG. 17.14 The production of a complete TCR peptide chain. Note
the similarities between this and Fig. 17.7.

Gene Rearrangement

TCR α and γ chains are constructed using only V, J, and C genes.
TCR β and δ chains use V, D, J, and C genes and can use multiple D
genes. As a result, V-D-D-J or longer constructs can be formed. This

amount of recombination also means that the reading frame of the
D genes may change and can yield productive rearrangements.

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