Page 13 - Avoid Food and Drug Interactions

© 2019 ASPEN | American Society for Parenteral and Enteral Nutrition. All Rights Reserved. Limitations of PN or Nutrition Support Research

• Methodological issues1
o Control for severity of malnutrition
o Quantity and type of substrates provided varies and not optimal2,3

• Glucose control: inconsistent criteria for abnormality2,3

• Questionable applicability of data from early trials to current practice

1Klein S, et al. J Parenter Enter Nutr 21:133, 1997 21
2August DA et al. JPEN 33(5):472-500, 2009
3McClave et al. JPEN 33(3):277-316, 2009

Dates of Evidence for ASPEN Critical Care and Cancer Guidelines1,2

Guideline References (Evidence)

4

3

© 2019 ASPEN | American Society for Parenteral and Enteral Nutrition. All Rights Reserved. 2 Cancer
Number per Year Critical Care

1

0 1975 1980 1985 1990 1995 2000 2005 2010
1970

Year Published

1.75 BEE Fat as 30 Cal/kg 28 Cal/kg
1-1.5 g calorie 1-2 g 1.5-2 g Pro/kg
Pro/kg/d source Pro/kg 22% Cal as ILE
Dextrose based 50% Non- 30% Cal as Glucose
protein ILE control
1August DA et al. JPEN 33(5):472-500, 2009 Cal
2McClave et al. JPEN 33(3):277-316, 2009 22

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