Page 124 - The Manga Guide to Biochemistry
P. 124
That’s right. And scientists have done experiments with leptin too—mice with
deformed leptin genes end up just as tubby as the mice without insulin receptors.
That’s awful! I wonder why scientists are always picking on mice, anyway...
If we compare the leptin concentration in the blood of nonobese people versus obese
people, they both have a value that is proportional to the amount of fat they carry.
The amount of leptin created by people who overeat is no different than
that of people who eat normally. Although the creation of leptin is linked with the
suppression of eating in nonobese people, this is not the case in obese people. In
other words, obese people are thought to have a resistance to leptin.
Getting NEECDH.IMPSO!RE.
pretty full...
chips
chips
Leptin
Leptin working Leptin not working
normally normally
What a nightmare! If our insulin or leptin is ineffective, we’ll eat and eat, and our
appetite will never be satisfied...
There are also a number of other substances that help balance our fat levels and
appetite, which we’ll talk about next!
110 Chapter 3
