Page 126 - The Manga Guide to Biochemistry
P. 126

First, we'll talk                       Normally, ingested
    about when                       lipids are solubilized

ingested lipids                            in the form of
  are directly                         lipoproteins, as we
  accumulated                         learned earlier, and
        as fat.                      circulate through the
                                    entire body where they
                    Lipid           undergo various kinds

                                           of respiration.

                                                                    Right, like the spheres
                                                                   we saw when we talked

                                                                      about cholesterol!

                           But if you ingest              BWAAA!
                           too many lipids...

                                the excess ends up
                              steadily accumulating
                             in the liver or adipose

                                 tissue in the form
                                            of fat.

     When we're talking about fat
     accumulation, we have to talk
about the indispensible work of an
 enzyme called lipoprotein lipase.

lipoprotein     enzyme                                          Since enzymes are
     lipase                                                     very important to
                                                          biochemistry, we'll study
                                                             them carefully later!

                           Fatty                          (details are in
                            Acid                            chapter 4.)

                                                 Adipose                   Aw
                                                  tissue

 Very low-   Chylomicron
    density   lipoprotein

lipoprotein                Glycerol

Over-ingested                                             enzyme
        lipids
                    Lipids and triacylglycerol
                 that were transported in the
                blood are hydrolyzed* by this
                enzyme to form fatty acid and
                glycerol, which are then taken

                           into adipose tissue.

112 Chapter 3                        * Hydrolysis is the decomposition of a substance by an
                                        enzyme using water. FOr details, see page 172.
   121   122   123   124   125   126   127   128   129   130   131