Page 127 - The Manga Guide to Biochemistry
P. 127

liver         small                          There are four main steps
            intestine                        to the process that turns

                                               ingested lipids into fat.

                                                       Let's take a look!

    VLDL and                           VLDL        chylomicron
Chylomicron
                                       triacylglycerol
                     Fat Cell
                                             lipoprotein lipase                        Blood
                                                                                      vessel
                               fatty acid          glycerol
                                                                     endothelial
                                                                            cell

                                       fatty acid  glycerol

                               Energy        Recombined and stored
                               source            in triacylglycerol

            Triacylglycerol is transported in the blood by very low-              Break it
            density lipoprotein (VLDL) that was created in the liver and           down!
            by chylomicron that was absorbed and created in the small
            intestine.                                                                 enzyme

            Endothelial cells, which line blood vessels, have an enzyme called
            lipoprotein lipase on their surfaces. When triacylglycerol is trans-
            ported through the capillaries in adipose tissue, muscles, and
            other tissues, it encounters lipoprotein lipase and is hydrolyzed
            into fatty acids and glycerol.

            Those fatty acids and glycerol are captured in adipose tissue.

            The captured fatty acids and glycerol are recombined and stored
            in triacylglycerol.

       Ooh                     And when this happens,
                               fat steadily increases!
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