Page 129 - The Manga Guide to Biochemistry

Now let's take a First, do you It went
closer look at how remember the around and
citric acid cycle? around, right?
saccharides turn I remember!
into fat.

saccharide

I'm
back!

Saccharides, which Saccharide
are an energy (glucose)

source, are broken Pyruvate Acetyl-CoA
down via glycolysis
Oxaloacetate Citrate
into pyruvate.
malate Citric acid cis-Aconitate
This pyruvate enters Fumarate cycle Isocitrate
the mitochondrion
Succinate α-ketoglutarate
and becomes acetyl-
CoA. We'll stop here Succinyl-
CoA
for now, okay?

Got it.

Normally, acetyl- if too many saccharides are
CoA combines with ingested, excess citrate
oxaloacetate to
become citrate, but... leaves the mitochondrion,
enters the cytosol, and is
Keep your
eye on the converted to fatty acid.

Ack!