Page 134 - The Manga Guide to Biochemistry
P. 134

Um...what in the world is β-oxidation?

Relax, I’m getting to it! Take a look at this diagram.

              j Fatty Acid                              eight molecules
              k Acyl-CoA                                  of Acetyl-CoA

Cytoplasm

              l Acyl-carnitine                          Palmitic Acid (C 16 )

                                                                              This process
                                                                               is repeated
                                                                                many times.

              Acyl-CoA again

Mitochondria                     There are two
                                 fewer carbon
                              atoms in Acyl-Coa.
              Acetyl-CoA

                               Citrate

               Citric acid
                   cycle

                                                        β-oxidation

                          Fatty acid becomes acetyl-CoA through β-oxidation. Remember when we talked
                          about acetyl-CoA earlier? (See page 115.)
                          It’s the stuff that appears in the first step of the citric acid cycle, right?

120 Chapter 3
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