Page 133 - The Manga Guide to Biochemistry
P. 133

Now let’s talk about how fat is metabolized.
      First, the fat in adipose tissue, triacylglycerol, is broken down into fatty acid

and glycerol by an enzyme called hydrolase. Hydrolase is a hormone-sensitive
lipase—note that this is different from a lipoprotein lipase, which we talked about
on page 112.

                             hydrolase     fatty               β-oxidation
                Lipase                      acid

            Fat                         Glycerol
triacylglycerol

Fatty acid is released into the blood and transported to the various organs and
muscles of the body, where it undergoes a chemical reaction called β-oxidation
(that’s beta oxidation).

         Triacylglycerol                          hydrolase

adipose  hormone-sensitive lipase
 tissue

         Fatty acid                     glycerol

         Fatty acid                     glycerol  endothelial
                                                        cell

                                                               blood
                                                               vessel

         Fatty acid                     glycerol

Through blood vessels
to organs and muscles

         β-0xidation

                                        Biochemistry in Our Everyday Lives  119
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