Page 130 - The Manga Guide to Biochemistry
P. 130

When too many                                              Since glycolysis is still
                                                           processing saccharide,
saccharides are                                            the malonyl-CoA, acetyl-
                                                          Coa, and palmitic acid will
ingested, citrate exits                                    accumulate, won't they?

into the cytoplasm,

is broken back down                            Palmitic
                                                  Acid
   into acetyl-CoA, and   Glucose
becomes the substance

called malonyl-CoA.                            Malonyl-
                                                    CoA
                          Pyruvate
                                                 Acetyl-
               Cytoplasm                             CoA

                                                             Ooooh

                          Acetyl-CoA

                                      Citrate

               Oxaloacetate                                Citrate Does
                                                          not enter the

                                                             citric acid
                                                                 cycle!

mitochondria

That's right, and palmitic
    acid is a fatty acid!

                                               Eep!

               If Malonyl-CoA is produced,
                 it ends up being directly

               converted into a fatty acid.

You should also be             Fructose promotes fatty               Woe is me...
careful about how           acid synthesis in the liver and          Betrayed by
                                                             sweet, sweet sugar...
  much table sugar            is one of the contributing
(fructose) you eat.                  factors to obesity.

116 Chapter 3
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