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44. MOLÉCULES EN DÉVELOPPEMENT                          857

             SUBSTANCES NATURELLES
             HARRIS C.R., DANISHEFSKY S.J., Complex target-oriented synthesis in the drug dis-
               covery process : a case history in the dEpoB series, J. Org. Chem., 1999, 64, 8434-
               8456.
             NICOLAOU K.C. et al., Chemistry, biology and medicine of selected tubulin polymerizing
               agents, Pure Appl. Chem., 1999, 71 (6), 989-997.
             WERNERT N. et al., Inhibition ofangiogenesisin vivo by ets-1 antisense oligonucleotides
               - Inhibition of Ets-1 transcription factor expression by the antibiotic fumagillin, Angew.
               Chem. Int. Ed., 1999, 38, 3228-3231.
             MARTI NEZ E.J., COREY E.J., A new, more efficient, and effective process for the syn-
               thesis of a key pentacyclic intermediate for production of ecteinascidin and phthasci-
               din antitumor agents, 2000, Org. Lett., 2000, 2 (7), 993-996.
             MULZER J. et al., Total syntheses of epothilones Band D, J. Org. Chem., 2000, 65, 7456-
               7467.
             SUPKO J.G. et al., A phase I clinical and pharmacokinetic study of the dolastatin analo-
               gue cemadotin administered as a 5-day continuous intravenous infusion, CancerChe-
               mother. Pharmacol., 2000, 46, 319-328.
             PRUDHOMME M., Recent developments of rebeccamycin analogues as topoisomerase
               1 inhibitors and antitumor agents, Curr. Med. Chem., 2000, 7, 1189-1212.
             KOHNO J. et al., Structure of TMC-69, a new antitumor antibiotic from Chrysosporium
               sp. TC 1068, Tetrahedron, 2001, 57, 1731-1735.
             BOGER D. et al., Total syntheses of thiocoraline and BE-22179 and assessment of their
               DNA binding and biological properties, J. Amer. Chem. Soc., 2001, 123, 561-568.
             CHIOSIS G. et al., A small molecule designed to bind to the adenine nucleotide pocket
               of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast
               cancer cells, Chem. Biol., 2001, 8, 289-299.
             Dl CHENNA P.H. et al., Preparation and cytotoxicity toward cancer cells of mono(aryli-
               mino) derivatives of B-lapachone, J. Med. Chem., 2001, 44, 2486-2489.
             MU F. et al., Design, synthesis, and biological evaluation of a series of lavendustin A
               analogues that inhibit EGFR and syk tyrosine kinases, as well as tubulin polymeriza-
               tion, J. Med. Chem., 2001, 44, 441-452.
             KRISHNAN P., BASTOW K.F., Novel mechanism of cellular DNA topoisomerase Il inhi-
               bition by the pyranonaphthoquinone derivatives a-lapachone and B-lapachone, Can-
               cer Chemother. Pharmacol., 2001, 47, 187-198.
             McMORRIS T.C. et al., Structure-activity studies of antitumor agent irofulven (hydroxy-
               methylacylfulvene) and analogues, J. Org. Chem., 2001, 66, 6158-6163.
             SINGH S.B. et al., Structure, histone deacetylase, and antiprotozoal activities of apici-
               dlns Band C, congeners of apicidin with proline and valine substitutions, Org. Lett.,
               2001, 3 (18), 2815-2818.
             TIETZE L.F. et al., A strategy for tumor-selective chemotherapy by enzymatic liberation
               of seco-duocarmycin SA-derivatives from nontoxic prodrugs, Bioorg. Med. Chem.,
               2001, 9, 1929-1939.
             BOGER D. et al., Synthesis and evaluation of a series of C3-substltuted CBI analogues
               of CC-1065 and the duocarmycins, J. Org. Chem., 2001, 66, 5163-5173.
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