Page 106 - Medicinal Chemistry Self Assessment
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Section 3  General Self Assessment Answers






                                                   2.1 Functional Group Characteristics
             Structures for 1.1 and 2.1
                                                                                              and Roles
             The bold has been removed.  The exact same structures are in both of these chapters, but I have provided two

             copies in the event you wanted that.


            1.  Shown below are the structures of warfarin, phenytoin, bromfenac, and salmeterol.
                a.  Identify each of the boxed functional groups.

                          A
                                                                                                  F

                                               C

                                                                               E


                                                                   D
                  Warfarin        B                                                     Bromfenac          G
                                                      Phenytoin






                           H
                                                    J         K
                              I                                         L

                                                        Salmeterol

                Answer

                Box            Functional Group Name

                      A        β-Dicarbonyl (enol form)
                      B        Ketone          B                                          D
                      C     A Phenyl ring; aromatic ring; aromatic hydrocarbon  C  O          CH
                                                O
                      D        Imide                            H  N            S  N              3
                      E        Halogen (bromo)  OH               2                 H    N   O
                      F        Primary aromatic amine; aniline                 O
                      G        Carboxylic acid                          Sulfamethoxazole
                                    Ibuprofen
                      H        Primary hydroxyl group or primary alcohol
                      I        Phenol or phenolic hydroxyl group
                      J        Secondary amine
                      K        Alkyl chain; aliphatic alkane
                      L        Ether



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