Page 144 - Medicinal Chemistry Self Assessment
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2.8  Aliskiren        133
















                                                                        C












                                                                        D












                                                                       E






                    Answer
                                        5.  Renin  catalyzes  the  cleavage  of  a  specific  Leu-Val  peptide  bond  within  the  structure  of  side
                           Name of Metabolic Transformation          Oxidative or Non-Oxidative
                                                                     Oxidative
                     A     Oxidative O-dealkylation chains of these two amino acids and box the non-hydrolyzable hydroxyethylene group.
                     B     Alcohol oxidation                         Oxidative

                     C     Oxidative deamination                     Oxidative
                     D     Oxidative O-dealkylation*                 Oxidative
                     E     Amide hydrolysis*                         Non-oxidative
                    * This metabolite has been identified as one of the two primary metabolites produced.
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