Page 187 - Medicinal Chemistry Self Assessment

6. Shown below is the to perform with haloperidol.

6. Shown below is the to perform with haloperidol.

176 Medicinal Chemistry Self Assessment
Answer
A. Reduction: Phase I, Yes
Answer
Answer

A. Reduction: Phase I, Yes
A. Reduction: Phase I, Yes

B. Sulfate conjugation is a phase II transformation. It is possible; however, due to steric hindrance,
B. Sulfate conjugation is a phase II ation is low.
the probability of this metabolic transformation is low.
B. Sulfate conjugation is a phase II ation is low.

C. Hydrolysis is a phase I transformation. It is not possible for haloperidol because its structure does
C. Hydrolysis is a phase I biotransformation.
not contain a functional group that undergoes this type of transformation.
D. Oxidative N-Dealkylation: Phase I, Yes
D. Oxidative N-Dealkylation: Phase I, Yes

C. Hydrolysis is a phase I biotransformation.

E. Benzylic oxidation is a phase I transformation. It is not possible for haloperidol because one
benzylic position is occupied by a ketone (and therefore is not capable of being oxidized) and the
other is directly attached to a heteroatom and lacks a hydrogen atom.