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Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)
The genins of all cardiac glycosides are
steroidal in nature
Characteristic features of cardiac glycosides: Aglycones :
➢ steroid nucleus (cyclopentanoperhydrophenanthrene (23 C atoms)
➢ unsaturated 5- or 6- membered lactone ring attached at C-17.
According to the type of lactone ring cardiac glycosides are:
➢ cardinolides with 5 membered lactone (e.g: Digitalis)
bufadienolides with 6- membered lactone (e.g: Squill).
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