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Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

General Structure:

• A tertiary -hydroxy group at C-14

• An axially oriented -hydroxy group at C-3 to which is attached the sugar residue

• A cis- fusion of the ring C/D and in most cases also of the rings A/B, while the B/C
ring junction is always trans.

• Methyl groups at C-10 and C-13. In addition, the steroidal nucleus may show variable
substituents such as: R: The methyl group at C-10 may be replaced by a CHO or
CH2OH group (e.g. Strophanthus glycosides), Additional hydroxy groups may be
present at C-1, C-2, C-5, C-11, C-12 &C-16

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