Page 291 - Pharmacognosy 2 PG303
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Pharmacognosy-2 (PG303)                              Level 2                Clinical Pharmacy-Pharm D

                  Chemical        ➢  On  micro-                                        ■  Test for
                  tests              sublimation  ,                                       Anthraquinones
                                      powdered                                            (Bornträger's  test) :
                                      Hydrastis yields a                                  pink color in the
                                     yellow crystalline                                   ammoniacal layer
                                     sublimate of                                         (aqueous layer)
                                     hydrastine .                                          ■  Others???
                                  ➢  Shake powdered                                    ❖  Rheum raponticum
                                     Hydrastis with                                       contains rhaponticin
                                     CHCl3       filter,                                  which is a stilbene
                                     evaporate the                                        derivative that has
                                     filtrate to dryness,                                 estrogenic effect .

                                  ▪  Residue + H2SO4 +                                 ➢  It can be detected in
                                     small crystal of                                     the official drug by:
                                     ammonium                                          ✓  It gives blue
                                     molybdate ,a green                                   fluorescence in UV
                                     color changed to                                     radiation unlike
                                     blue.                                                rhubarb gives reddish

                                  ▪  Residue + H2SO4  +                                   brown fluorescence .
                                     few drops of                                      ✓  Furfural test:
                                     bromine ,a blood-                                    furfural  dps  of
                                                                                                        .
                                                                                                   +
                                     red color is                                         conc .H₂SO₄  little
                                                                                                       +
                                     produced .                                           powder if rhapontic
                                                                                          gives
                                                                                          violet color .

                  Uses            ▪  anti -inflammatory     ▪  Expectorant  :          ■  Depending on the        ▪  It resembles digitalis  Rat poison


                                     for the uterine            used in bronchitis        dose ,rhubarb can be        in its action on the     (Rodenticide)
                                     mucous membrane .      ▪  Emetine has                used as:                    heart  .It increases the

                                                                                    .
                                  ▪  isoquinoline alkaloid      amoebicidal activity   -  Laxative )1-2 g)            strength and reduces
                                     constituents           ▪  Larger amount of        -  Astringent and              the frequency of the
                                     (Antibiotic ,              the drug is a strong      stomachic )0.1-0.2g)        cardiac action .

                                     Immunostimulant  ,         emetic .                                          ▪  It is a powerful
                                     Anticonvulsant  ,                                                                expectorant  &

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