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Floppy infant
Definition:
Sever persistent hypotonia present at birth or early infancy
Causes :
➢ Cerebral :
Perinatal asphyxia.
Kernicterus.
Cerebral palsy (atonic type).
➢ Chromosomal anomalies including down syndrome.
➢ Spinal cord lesion:
Anterior horn cell disease (Werding Hoffman spinal muscular atrophy).
Early extensive poliomyelitis.
➢ Peripheral nerves
Acute polyneuropathy.
Guilllain Barre Syndrome (GBS)
Congenital sensory neuropathy.
➢ Neuromuscular :
Neonatal myasthenia gravis Infantile botulism
➢ Myopathies :
Muscular dystrophies. Congenital myopathies. Polymyositis.
