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UNIT 1
               MODULE 2: GENETICS, VARIATION AND NATURAL SELECTION (cont’d)


                SPECIFIC OBJECTIVES                  EXPLANATORY NOTES           SUGGESTED PRACTICAL
                                                                                 ACTIVITIES

                3.        Patterns of Inheritance

                Students should be able to:

                3.1.     use   genetic   diagrams   to    Gene,  allele,  dominant,   Analyse  seed  samples  of
                         solve      problems  involving   recessive,  codominant,   peas   for   Mendelian
                         monohybrid  and  dihybrid   homozygous,                 dihybrid ratio.
                         crosses;                    heterozygous,       sex
                                                     linkages,  codominance
                                                     multiple   alleles   and
                                                     dominant      epistasis.
                                                     Candidates       should
                                                     understand the ratios.

                3.2.     analyse  the  results  of  a   Formulae  will  be  given.
                         genetic  cross  by  applying   Set  out  data  in  tabular
                         the Chi-square test; and,   form.

                3.3.     determine  whether  the     The      concept     of
                         difference  between  the    probability.   Explanation
                         observed  and  expected     of  the  use  of  0.05
                         ratio is significant using the   confidence limits and the
                         results  of  the  Chi-square   null hypothesis.
                         test.

                4.        Aspects of Genetic Engineering

                Students should be able to:

                4.1.     outline  the  principles  of   Restriction  enzymes  as
                         restriction  enzyme  use  to   “molecular  scissors”  and
                         “cut” sections of DNA and   Ligase    enzyme      as
                         ligase  enzyme  to  “paste”   “molecular      glue”.
                         DNA together;               Importance    of   these
                                                     classes  of  enzymes  in
                                                     development  of  R-DNA
                                                     technology.     Mention
                                                     advanced genome editing
                                                     tools,  such  as  CRISPR-
                                                     Cas9.






                            CXC A10/U2/17
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