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UNIT 1
               MODULE 2: GENETICS, VARIATION AND NATURAL SELECTION


               GENERAL OBJECTIVES

               On completion of this Module, students should:

               1.      understand the structure of nucleic acids and their roles in protein synthesis and nuclear
                       division;

               2.      understand the behaviour of chromosomes, nucleus and cytoplasm in mitotic and meiotic cell
                       division and their importance for stability and variation in a species;

               3.      understand the patterns of inheritance;

               4.      understand  selected  aspects  of  genetic  engineering  and  its  medical,  agricultural,
                       environmental, ethical and social implications; and,

               5.      understand the genetic basis of variation and its importance in natural selection.


                SPECIFIC OBJECTIVES                  EXPLANATORY NOTES            SUGGESTED PRACTICAL
                                                                                  ACTIVITIES

                1.        Structure and Roles of Nucleic Acids

                Students should be able to:

                1.1.     compare  the  structure  of   Draw  a  nucleotide  using
                         RNA  and  DNA;              shapes;  recognise  (not
                                                     draw)    the    structural
                                                     formulae  of  nucleotides,
                                                     ribose,      deoxyribose,
                                                     pyrimidines,     purines;
                                                     nature of hydrogen bonds.

                1.2.     explain the importance of   Recognition    of     the
                         hydrogen  bonds and base    significance  of  5’  and  3’;
                         pairing in DNA replication;   semiconservative
                                                     replication; genetic code.

                1.3.     describe the roles of DNA   Different  types  of  RNA
                         and    RNA   in  protein    (tRNA,  rRNA  and  mRNA)
                         synthesis;                  and  their  respective  roles.
                  1.1                                Initiation,   transcription,
                                                     translation,  termination.





                            CXC A10/U2/17
                                                                  17
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