Page 157 - Pharmacology Mnemonics and Short Notes

149

Anticoagulants

1) Direct thrombin inhibitors

Based on Protein hirudin (Leach protein)

Drugs  Anty thrombin loves BD anatomy

o Lipirudin  recombinant form of Hirudin

o Bivaluridin  modified form of hirudin

o Dabigatran  orally active

o Argatroban  small molecule with lesser half life

Mechanism  Bind to thrombin and thrombin substrate
(argatroban only to thrombin)

Clinical uses

o tHrombin  alternative to heparin in patients with heparin
induced thrombocytopenia

o with aspirin in coronary artery angioplasty

Acivitymeasured by aPTT (activated prothrombin time)

Toxicity prolonged bleeding

2) Heparin

Mechanism

High molecular weight Heparin  inhibit thrombin and factor Xa

Contents

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman