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Non-depolarizing neuromuscular blocker  prevent attachment of
acetylcholine to nicotinic receptor  prevent depolarization of muscle
cell membrane  inhibit muscle cell contraction

 Effects overcome by increase Acetylcholine  by administration of
cholinesterase inhibitors.

At higher doses

Block the ion channel of the end plate  further weakness of
neuromuscular transmission.

 Effects not overcommed by increase of acetylcholine  because

the ion channel is Blocked

Actions

Muscle relaxation from smaller to larger muscles

 Diaphragm Muscles are last to paralysed.

Therapeutic usage

Adjuvant drugs in anesthesia  less anesthetic is needed to produce

muscle relaxation

Classification

 Tubocurarine

 Mivacurium

 Metocurium

 Desocurium

 Rocuronium

Vacuronium and rocuronium  are deacetylated in liver  clearance is
prolonged in hepatic disease.

LVR  liver
Contents Drug inter actions

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman