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1) Cholinesterase inhibitors

Neostigmine and physostigmine overcome action of

nondepolarizing neuromuscular blockers

2) Halogenated hydrocarbon anesthetics

Increase neuromuscular blockage  like halothane

3) Aminoglycoside antibiotics

Gentamicin and toberamicin  inhibit Acetylcholine release by
+2
inhibiting Ca release
4) Ca channel blockers

Increase neuromuscular blockage

Depolarizing neuromuscular blockers

Succinylcholine.

Mechanism

Attaches to Nicotinic receptors  persist at high concentration in
synaptic cleft and remain attached to the receptor for longer time 
provide constant stimulation.

Phase I

Membrane depolarization result in initial discharge which produces
transient fasciculations followed by flaccid paralysis

Phase II

Full neuromuscular blockage is achieved and receptor is desensitized to
effect of acetylcholine

 Now receptor is resistant to depolarization (closed or blocked)

Actions

Contents Sequence of paralysis little different.

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman