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P  phenelezine

Mechanism

 Inhibit MAO (Monoamine oxidase enzyme)  catabolism of amines
(Dopamine) inhibited

 Used as adjuncts with levodopa in treatment of parkinsonism

Muscarinic Inhibitors

Muben  Mu + ben  Muscarinic inhibitors  durug is benztropine

Mechanism

 Block muscarinic receptors

Uses

 Improve tremors and rigidity but not bradycardia

Adverse effect

 Muscarinic inhibitors (ANS section for side-effects)

Dopamine precursors

Levodopa and Carbidopa are used

 Levodopa  metabolic precursor of dopamine and this restores
the dopamine level in extrapyramidal centres

o Provide symptomatic relief that last only when drug is
present in body

 Carbidopa  inhibit peripheral metabolism of Levodopa

Mechanism

Parkinsonism  decrease level of dopamine in specific regions of brain

Contents

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman