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COMT inhibitors (catechol o methyl transferase)

Capones

 Entacapone

 Tolcapone

Mechanism

 Block levodopa metabolism in periphery

Uses

 Prolong levodopa actions

Tourette’s syndrome

 Haloperidol  D 2 blocker

 Clonidine  alpha 2 blocker

Use

 Reduce vocal and motor tic frequency

Contents

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman