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Dopamine  cannot cross blood brain barrier

Levodopa  immediate precursor of dopamine & can cross blood brain

barrier

Carbidopa  inhibit peripheral metabolism of Levodopa and cannot
cross blood brain barrier SO metabolism inside brain will not be effected
 Lower dose of levodopa to 4 to 5 folds and decrease severity of side

effects

Therapeutic uses

Levodopa in combination with Carbidopa is potent and efficacious drug
regime currently available

 Decrease severity of disease for few years

Absorption and metabolism

 Absorbed rapidly from small intestine

 Half-life 2-3 hours

Contents

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman