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Roz (rose) from Quetta came

R  Risperidone

O  Olanzapine

Z  Ziprasidone

From  says  5HT 2 receptor
affinity

Queta  Quetiapine

USES

Antipsychotics  AntiPSychotics

A  treatment of agitated state

P  Psychosis

S  Schizophrenia

PHARMAKOKINETICS

 Lipid soluble readily enter CNS
 Hepatic metabolism

Mechanism of action

 Dopamine hypothesis (older)

 Serotonin hypothesis (new)
1) Dopamine hypothesis

 Schizophrenia  is due to excess of functional activity of

neurotransmitter dopamine in specific brain tracts
 Dopamine tracts (multinational technical college)

 Mesocortical & mesolimbic pathway
 Nigrostriatal tract

 Tuberoinfundibular tract
Contents  Chemoreceptor trigger zone

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman