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o Food containing amines (cheese effect)

o Hypertensive crisis are produced (tyramine displaces

norepinephrine from storage vesicles) (or causes
accumulation of catocholamines)

o Examples  liver, soyabean and aged cheese

 Food containing tryptophan  hyperserotonemia  fatal

serotonin syndrome developed

 Should not be combined with other antipsychotics  certain
combination may prove lethal  like with SSRIs and tricyclics

 Addictive potential of Nicotine (component of tobacco) is
increased result difficulty in cessation of smoking.

 Cause hypertension with sympathomimetics

Tricyclic antidepressants

CIA is after cyclics

C  Clomipramine

I  imipramine
A  amitriptyline

Mechanism

Block nor-epinephrine and 5HT transporter

Uses

 Major depressive disorders

 Bipolar disorders

 Generalized anxiety disorders

 Post-traumatic stress disorders

Contents  Body dysmorphic disorders

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman