Page 240 - Pharmacology Mnemonics and Short Notes

232

Lithium.

Uses

Lithium  ends on M used in manic phase of bipolar disorder

 Prevention and treatment of manic and depressive episodes

Mechanism

 Inhibit several enzymes involved in recycling of neuronal
membrane phosphatides.

 Result Suppress IP3 and DAG signaling

Adverse effects

Lithium

L  leucocytosis

I  inspidus (diabetes)

T  tremors and teratogenic

H  hypothyroidism

I  increased weight

U  v  vomit

+
M  regular monitoring (because Li interfere Na and H 2O levels in
body

Other used as antipsychotic (VLC)

V  valproic acid

L  lamotrigine

C  carbamazepine

Contents

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman