Page 235 - Pharmacology Mnemonics and Short Notes

227

 Fluctuations in plasma concentration produces  Fluctuations in
motor response (ON OFF phenomena)  sudden loss of mobility

and tremors

Dietry interactions

 High protein meal  interfere transport of levodopa (leucine and
isoleucine compete with this drug for absorption and transport.

 Taken empty stomach 45 min before meal

Adverse effects

LEVODOPA

L  lower blood pressure and loss of hairs

E  emesis  stimulate emetic centre

V  ventricular extrasystole

D  dyskinesia

o o
O  ( I )  o resemble eye  Visual and auditory hallucinations
P  protein interference with Levodopa  nausea

A  Anorexia

Interactions

 Vit B 12  increase peripheral breakdown of levodopa

 Antipsychotic drugs  contraindicated in patients of parkinsonism
 exacerbate symptoms

Dopamine agonists

Bromocriptine (D 2 agonist) and pramipexol (D 3 agonist)

Uses

 Used in early treatment of parkinsonism
Contents  Adjuncts to levodopa in treatment of parkinsonism

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman